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Modafinil for increasing of stamina, energy and attention.Modafinil - benzigidrilsulfine-latsetamid, is a newest stimulant medicine created by Lafon Laboratories (France). It doesn`t have the same name in each country, for example, in the U.S. it is called provigil, in other countries - Modiodal, Alertek. One of the most effective versions of generic Modafinil is Modalert manufactured by Sunpharma. The content of the substance modafinil is up to 97% Designed to treat narcolepsy, Modalert (uncontrollable episodes of deep sleep) helps to fight tiredness and excessive sleepiness. The analyses are made for its possible use against Alzheimer's disease, depression and attention disorders. The medicine was synthesized in the late 70s of the last century by a French pharmaceutical company Lafon Group. In 1986, the test results showed that the medicine was efficient not only against narcolepsy, but it also helped patients not to feel need for sleep. In 1994 France was the first to begin the fabrication of pills based on this drug. In 1993, the Lafon Group sold the rights of utilization of this medecine to the US company Cephalon. In December 1998, the FDA authorized the sale of modafinil (under the name "provigil") as a remedy against narcolepsy. The use of modafinil as a stimulant showed that it`s much more efficient than amphetamines. It`s practically not addictive, it does not cause intense euphoria, reduces peripheral stimulation of CNS, has a minimal impact on blood pressure, it does not cause a hangover after sleeping, and it also showed a very high level of safety during clinical trials. This drug is used in the Air Force and U.S. Army to reinforce attention and performance of pilots and soldiers. Before, another medicine, Dexedrine, was used for this purpose. It belongs to an amphetamine group, but it had such side effects as anxiety, anger, and sense of powerlessness. The soldiers say that modafinil allows them to be efficient for 40 hours without sleep. Modafinil has been successfully tested in Afghanistan and Iraq. Modafinil is more and more used for athletic competitions not only to keep awake, but also to increase endurance. Canada`s scientists made a study proving the efficiency of the drug. 15 male athletes under test were receiving either a dose of 4 mg per kg ( of body weight) of modafinil or placebo. Three hours after taking drugs, the men were working to total exhaustion. Those who took modafinil, stood at the average 30% longer. A typical dose for men and women is about 100-400mg (Modalert 200mg x 2)and it has to be taken 2-3 hours before competition. It`s recommended to gradually increase the dosage for 50-100mg before reaching a needed level. This drug can be used in practically any sport, but the most of all its usage is necessary in the sports requiring stamina and for short repeated exercises such as weightlifting. Helicopter pilots taking 600 mg of modafinil divided in 3 doses, were capable to work during 88 hours with only 8 hours of sleep. Other tests show that F-117 pilots with a lack of sleep receiving 300 mg of modafinil (3 doses of 100), kept about 27 percent of their capacity to control an aircraft. The only side effect of the medicine found during its studies and sale (Alertec, Provigil) are rare cases of mild nausea and headaches. Dosage: If you just want to relieve your fatigue, you have to take a single dose of 100 mg. Being efficient all day long will require 100 mg in the morning and 100 mg at a lunch time. To keep awake at night add 100 mg dose in the evening (in other words 100 mg every 8 hours) IndicationsBesides narcolepsy Modafinil is also recommended to people with attention deficit disorder, resistant depression and disseminated sclerosis as well as an additional medicine during antidepressant therapy. Its ability to considerably increase human endurance, the effects similar to those of amphetamine and the increasing number of athletes implicated in its use on international competitions made that Modafil was listed as a dope and prohibited by the World Anti-Doping Agency. It quickly gained popularity among drivers, sportsmen, programmers, shift workers. Its application domain is quite large. It can be used in fibromyalgia therapy, chronic fatigue syndrome, myotonic dystrophy, spastic cerebral palsy and Parkinson's disease. In recent years, Modafinil is often used as a highly efficient mean to lower appetite and lose weight. According to studies, appetite decreases for at least 38% that brings to a rapid weight loss. Today scientists are considering the possibility of using Modafinil for patients with cocaine addiction, primary biliary cirrhosis and bipolar disorder. However, Modafinil, allowing a person to stay awake for a long time, can be used not only by people suffering from pathological sleepiness (narcolepsy) but also by healthy people who have to stay awake for some reason (eg, rescue workers, firefighters, etc ). This pharmaceutical product is made by Cephalon, Inc. under the brand name 'Provigil'. Perhaps, new FDA decision concerning modafinil will help to increase sales and profits for its producers. However, there is a danger that the drug will be used by students or night club visitors. Although the producer of the drug asserts that side effects are rare, and they are not serious, its taking shouldn't be uncontrolled. For the moment, there is only one category of people to whom this drug is strictly prohibited by the World Anti-Mofalert. Dosage, interaction and side effects. Modalert (Modafinil) helps many people who must be in a good form and full of energy to use their potential for achieving their goals. It is a powerful stimulant, improving memory, intellect acuity, and other parameters of mental activity. Modafinil is one of the best ways to stimulate mental activity, reduce need for sleep and treat depression, it`s efficient in taking off the weariness and restoring cognitive function of the brain.. An absence of side effects such as addiction, low sens of responsibility and overexcitation are very important. The drug is produced in the form of pills and powder. You have to take into account that pills contain a number of auxiliary substances that affects the dosage of the drug. The standard prescribed dose is 200 mg once a day (rare 100 to 400 mg per day in one or two steps). Modalert is usually taken in one dose in the morning or in two doses in the morning and at noon. As a rule, modafinil should not be taken in the afternoon, because it carries a risk of sleep disorders. It is a drug with a long half-life and can stay in the body up to 15 hours. How does it help?It increases the release of monoamines, histamine level in the hypothalamus (the source). It is not a narcotic. Safety and side effectsIt may cause headache, nausea, nervousness, anxiety, dizziness, sleep disturbances. If any of these symptoms persist for a long time or intensifies, consult your doctor immediately. Remember that if your doctor prescribed you modafinil, he thinks that a benefit from using it is higher than a possible risk of side effects. Many patients treated with this medicine do not have serious side effects. Immediately consult your doctor if you have one of the following (rare but serious) side effects: change in mental state or mood, agitation, confusion, depression, distorted thinking, hallucinations. Call emergency if you have any of the following (rare but extremely serious) side effects: chest pain, accelerated, enhanced, or uneven heartbeat, signs of infection (fever, constant sore throat). Strong allergic reaction is hardly probable. However, stop taking modafinil and immediately see your doctor if you observe any of the following symptoms: skin rash, itching / swelling (especially on face, tongue or throat), blisters or skin peeling, severe dizziness, heavy breathing. The use of this medicine is contra-indicated if you have some of the following diseases: heart disease called "left ventricular hypertrophy," bad reaction to stimulants (chest pain, irregular heartbeat). Before you order Modalert, notify your doctor about existing and past illnesses, especially about blood pressure boosts, cardiac problems (chest pain, myocardial infarction, the disruption of the heart valves), liver problems, kidney disease, mental disorders and mood changes (mania, psychosis), personal or family regular use or drug or alcohol abuse. Sleep deprivation may reduce the capacity of rapid reaction. Despite the fact that modafinil helps to stay awake, it can disturb the ability to perform tasks requiring attention and cause somnolence. Pay attention when performing activities requiring attention, such as driving or technology control. Avoid alcohol. The above list of possible side effects is not exhaustive. If you experience any other unusual or adverse effect (other than listed above), please tell about them to your doctor. Interaction with other drugsNormally, your doctor is aware of possible reactions of modafinil with other drugs and your treatment is under control. Do not start taking medicine, don`t stop it yourself and do not change its dosage without consulting your doctor. Before taking the drug inform your doctor or pharmacist about all other medicines you are taking including prescribed and non prescibed drugs, and herbal remedies, especially drugs lowering blood pressure (beta-blockers - atenolol, metoprolol, clonidine, guanabenz, methyldopa, prazosin), anticoagulants (warfarin), drugs affecting hepatic enzymes activity that are involved in removing modafinil from the body (azole antifungals - itraconazole, ketoconazole, rifamycin - rifabutin, rifampin, anticonvulsants - carbamazepine, phenobarbital). Modafinil can affect the activity of certain liver enzymes by speeding up or slowing down the excretion of other drugs from the body such as certain antidepressants (eg tricyclic antidepressants - clomipramine, desipramine, SSRIs - fluoxetine, flyuvoksamin), cyclosporine, diazepam, phenytoin, propranolol, theophylline, triazolam. Avoid taking MAO inhibitors (furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) two weeks before, during and after taking modafinil. In some cases it can cause serious problems including death. Modafinil may decrease the effect of hormonal contraceptives (pills, patches, rings) and provoke an unwanted pregnancy. During the treatment period and within one month after it you are adviced to use other reliable means of contraception. For detailed information see your doctor or pharmacist. Specify the components of all your medicines (cough medicines, or SARS, food additives). It may contain ingredients (pseudoephedrine, ephedra / ma huang) increasing pressure and heart rate. Only your doctor or pharmacist can say if Modafinil is safe for you. Avoid drinking large amounts of liquids containing caffeine (coffee, tea, cola). It may increase the side effects of the drug. This description does not contain information about all the possible interactions with other drugs. In this regard, consult your doctor and let him know about all other drugs you are taking. |